Drug Index


Synonym :


Mechanism :

Chloroquine phosphate is a 4-aminoquinoline compound for oral administration. Chloroquine is an antimalarial and amoebicidal drug. The drug possesses antimalarial actions and exerts a beneficial effect in lupus erythematosus (chronic discoid or systemic) and acute or chronic rheumatoid arthritis. The precise mechanism of action is not known.

Indication :

  • Malaria (Vivax malaria)
  • Amoebic liver abscess
  • Juvenile idiopathic arthritis (JIA)
  • Porphyria
  • Systemic lupus erythematosus
  • Discoid lupus erythematosus
  • Polymorphic light eruptions
  • Rheumatoid Arthritis
  • Porphyria Cutaneous Tarda (off-label)

Contraindications :

Contraindicated in the presence of retinal or visual field changes attributable to any 4-aminoquinoline compound, in patients with known hypersensitivity to 4-aminoquinoline compounds, and for long-term therapy in children.

Dosing :


Oral.10 mg/kg as loading dose followed by 5 mg/kg after 6 hours. Then 5 mg/kg every 24 hours till total dose is 25 mg/kg.

Malaria Prophylaxis:

5 mg/kg base once PO a week. To be given 1-2 week before entering the area and to be continued for 4 weeks after return.

Other conditions:

5-6.5 mg/kg (Max: 400 mg) once daily. Adjusted according to plasma levels in severe renal and hepatic impairment.

Adverse Effect :

QT prolongation, nausea, diarrhoea, anorexia, abdominal cramps, irreversible retinal damage (rare), corneal opacities. skin rashes, pigmentary changes, bleaching of hair and hair loss, methemoglobinemia. Hydroxychloroquine may precipitate attacks of psoriasis.

Interaction :

Digoxin: Plasma digoxin levels may be increased.
Antacids: Ab­sorption of hydroxychloroquine may be reduced by antacids. Hydroxychloroquine may also be subject to the known interactions of chloroquine even though specific re­ports have not appeared.
Ampicillin: Chloroquine significantly reduced the bioavailability of ampicillin. An interval of at least two hours between intake of this agent and chloroquine should be observed.
Cyclosporin: After introduction of chloroquine, a sudden increase in serum cyclosporin level has been reported. Therefore, close monitoring of serum cyclosporin level is recommended.

Renal Dose :

Dose in Renal Impairment GFR (mL/min)
20-50Dose as in normal renal function
10-20Dose as in normal renal function
<1050% of normal dose

Dose in Patients undergoing Renal Replacement Therapies
CAPDNot dialysed. Dose as in GFR<10 mL/min
HDNot dialysed. Dose as in GFR<10 mL/min
HDF/High fluxUnknown dialysability. Dose as in GFR<10 mL/min
CAV/VVHDNot dialysed. Dose as in normal renal function

Hepatic Dose :

Chloroquine concentrates in the liver. No dosage adjustments are recommended.
03/20/2024 22:09:23 Chloroquine
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