Drug Index

Imiglucerase

 
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Mechanism :

Imiglucerase is an analogue of the human enzyme, (beta)-glucocerebrosidase produced by recombinant DNA technology. (beta)-Glucocerebrosidase is a lysosomal glycoprotein enzyme which catalyzes the hydrolysis of the glycolipid glucocerebroside to glucose and ceramide.


Indication :

• Type I Gaucher’s disease


Contraindications :

There are no known contraindications to the use of imiglucerase.


Dosing :

<2 years: Safety and efficacy not established.

>2 years: 2.5 units/kg given intravenously over 1-2 hours thrice a week or 30-60 units/kg given intravenously every 2 weeks.


Adverse Effect :

Hypersensitivity reactions have been reported, manifested by flushing, pruritus, urticaria, chest discomfort, angioedema, cyanosis, respiratory symptoms, and hypotension. Additional adverse reactions that have been reported include: fatigue, abdominal pain, diarrhea, nausea, backache, rash, headache, dizziness, fever with chills, and tachycardia.


Interaction :

No known drug interactions.


07/18/2019 11:53:28 Imiglucerase
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