Drug Index

Labetalol

 
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Mechanism :

Labetalol combines both selective, competitive, alpha1-adrenergic blocking and nonselective, competitive, beta-adrenergic blocking activity in a single substance.


Indication :

• Hypertension (off-label)

• Hypertensive crisis


Contraindications :

Labetalol is contraindicated in cardiogenic shock, sinus bradycardia and greater than first degree block, bronchial asthma, congestive heart failure unless the failure is secondary to a tachyarrhythmia treatable with Labetalol.


Dosing :

Hypertensive crisis: 0.4-1 mg/kg/hour by continuous intravenous infusion; Max: 3 mg/kg/hour.

Hypertension: 1-3 mg/kg/day given orally in two divided doses OR 0.3-1 mg/kg intermittently as an intravenous injection; Max: 1.2 g/day.


Adverse Effect :

Bradycardia, intermittent claudication, Raynaud’s phenomena, postural hypotension, precipitation of heart block, thrombocytopenia, hypoglycemia, confusion, hallucinations, dizziness, paraesthesia, mood changes, nightmares and tingling sensation of scalp. Respiratory effects are bronchospasm.


Interaction :

Calcium Channel Blockers: Additive effect.
Prostaglandin Synthase inhibiting drugs: Decrease the hypotensive effects of beta blockers.
Catecholamine-depleting drugs such as reserpine: Hypotension, marked bradycardia, vertigo, syncopal attacks, or orthostatic hypotension.
Haloperidol: Hypotension and cardiac arrest.
Theophylline: Clearance is reduced.
Cimetidine: Increasing blood levels.
Chlorpromazine: Increased plasma levels of both drugs.
Phenytoin, Phenobarbitone and Rifampin: Accelerate labetalol clearance.
Ethanol: Slows the rate of absorption of labetalol.
Aluminium Hydroxide Gel: Greatly reduces intestinal absorption of labetalol.


07/17/2019 11:14:27 Labetalol
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