Drug Index


Mechanism :

Docusate is a stool softener. It is used to treat constipation due to hard stools, in painful anorectal conditions such as hemorrhoids. The effect of docusate may not necessarily be all due to its surfactant properties. Perfusion studies suggest that docusates inhibit fluid absorption or stimulate secretion in jejunum.

Indication :

  • Painful anorectal conditions
  • Constipation (acts as a stool softener)

Contraindications :

Presence of abdominal pain, nausea or vomiting are contraindications.

Dosing :

Oral: Divide in 1-4 doses
<3 years:
10 to 40 mg daily.
3 to 6 years:
20 to 60 mg daily.
6 to 12 years:
40 to 150 mg daily.
>12 years:
50 to 400 mg daily.
3 to 18 years:
50 to 100 mg added to a retention or flushing enema once a day. As an enema: 200 to 283 mg once daily.

Adverse Effect :

Cramping, bitter taste, throat irritation, congestion of the rectal mucosa may occur following rectal use, intestinal obstruction.

Interaction :

Mineral oil: Increased absorption of the oil may result. Do not use in the presence of abdominal pain, nausea, fever or vomiting. Frequent or prolonged use may result in dependence on laxatives. Do not administer docusate within 2 hours of another medicine, to avoid reduction of its effect.

Hepatic Dose :

No dosage adjustments are recommended.
02/16/2021 03:43:58 Docusate
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