Drug Index

Lurasidone

 
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Mechanism :

Lurasidone is a benzisothiazol-derivative atypical antipsychotic with mixed serotonin-dopamine antagonist activity. It exhibits high affinity for D2, 5-HT2A, and 5-HT7 receptors; moderate affinity for alpha2C-adrenergic receptors; and is a partial agonist for 5-HT1A receptors.


Indication :

• Bipolar depression

• Schizophrenia

• Off-Label: Major depressive disorder with mixed features; Psychosis/agitation associated with dementia


Contraindications :

Hypersensitivity to lurasidone or any component of the formulation (including angioedema); concomitant use with strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin, ritonavir, voriconazole, mibefradil) and inducers (e.g., rifampin, avasimibe, St. John’s wort, phenytoin, carbamazepine).


Dosing :

Bipolar depression (Monotherapy):

Children ≥10 years of age and Adolescents: Oral: Initial: 20 mg once daily; may increase dose after 1 week based on response and tolerability; maximum recommended dose: 80 mg/day.

Schizophrenia: Adolescents: Oral: Initial: 40 mg once daily; may increase dose further based on response and tolerability; maximum recommended dose: 80 mg/day.


Adverse Effect :

Extrapyramidal reaction, drowsiness, akathisia, Parkinson-like-syndrome, insomnia, hyperglycemia, hypertriglyceridemia, nausea, viral infection, tachycardia, weight gain, vomiting, dyspepsia.


Interaction :

CYP3A4 Inducers: May decrease the serum concentration of Lurasidone.
CYP3A4 Inhibitors: May increase the serum concentration of Lurasidone.
Hydrocodone and Hydroxyzine: CNS Depressants may enhance the CNS depressant effect.
Metoclopramide: May enhance the adverse/toxic effect of Antipsychotic Agents.


07/14/2019 06:44:07 Lurasidone
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