Drug Index

Minoxidil

 
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Mechanism :

It is an anti-hypertensive drug with powerful vasodilator properties. It is used in the treatment of hypertension in children with renal disorders. It is also used to treat hair loss in adults as a topical agent.


Indication :

• Severe hypertension (in addition to beta blocker and diuretic)


Contraindications :

Pheochromocytoma, Use with caution in porphyria.


Dosing :

1 month-12 years: Initial: 200 mcg/kg (Max: 5 mg/day) and then increase to 0.25-1 mg/kg/day orally 1-2 times a day (Max: 50 mg/day).

12-18 years: Initial: 5 mg orally per day. Maintenance: 2.5-80 mg/day or every 12 hours. Max: 100 mg/day.

Increase every 3 days by 100-200 mcg/kg in those <12 years to a max of 1 mg/kg/day and by 5-10 mg/day to a max of 100 mg/day in those >12 years.


Adverse Effect :

Hypertrichosis, abnormal ECG, pericardial effusion, hypotension, pulse changes, headache, dizziness, sodium and water retention, tachycardia, weight gain, rash.


Interaction :

Antihypertensive Agents: Additive to other antihypertensive agents.



Renal Dose :

Dose in Renal Impairment GFR (mL/min)
20-50Start with small doses and titrate according to response.
10-20Start with small doses and titrate according to response.
<10Start with small doses and titrate according to response.

Dose in Patients undergoing Renal Replacement Therapies
CAPDDialysed. Dose as in GFR<10 mL/min
HDDialysed. Dose as in GFR<10 mL/min
HDF/High fluxDialysed. Dose as in GFR<10 mL/min
CAV/VVHDDialysed. Dose as in GFR=10-20 mL/min

Hepatic Dose :

No dose adjustments are recommended. Adjust dose as per clinical response.
05/21/2020 21:17:51 Minoxidil
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