Naphazoline
Mechanism :
It is a selective alpha 2 agonist and a nasal decongestant that acts by causing nasal vasoconstriction. It is combined with other drugs like anti-histamines, steroids for local use. It is used to treat nasal congestion and eustachian tube blockage.
Indication :
- Nasal congestion
- Sinusitis
Contraindications :
Hypersensitivity, Angle closure glaucoma, MAO inhibitor use in last 14 days.
Dosing :
1-2 sprays (0.05%) in each nostril every 6 hours and as and when needed.
Adverse Effect :
Prolonged use may cause atrophic rhinitis and anosmia. It may cause rebound congestion on stopping the drug. Burning, stinging, sneezing, dryness, local irritation are other side effects.
Interaction :
Drugs to be avoided include:
Isocarboxazid, Linezolid, Phenelzine, Procarbazine, Selegiline Transdermal, Tranylcypromine.
Hepatic Dose :
No dosage adjustments are recommended.