Drug Index

Pramipexole

 
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Mechanism :

Non-ergot dopamine agonist with specificity for the D2 subfamily dopamine receptor and has also been shown to bind to D3 and D4 receptors.


Indication :

• Treatment of Tourette syndrome in pediatric patients (Orphan drug)

• Parkinson disease

• Restless legs syndrome

• Off-label: Bipolar depression, fibromyalgia


Contraindications :

Hypersensitivity to pramipexole or any component of the formulation.


Dosing :

Restless leg syndrome:

>5 years: 0.125-0.375 mg PO at night. Start with 0.125 mg and increase every 4-7 days.


Adverse Effect :

Orthostatic hypotension, drowsiness, extrapyramidal reactions, insomnia, dizziness, hallucinations, nausea, constipation, dyskinesia, asthenia.


Interaction :

Antipsychotic Agents (First Generation [Typical]): May diminish the therapeutic effect of Anti-Parkinson Agents.
Antipsychotic Agents (Second Generation [Atypical]): May diminish the therapeutic effect of Anti-Parkinson Agents.
Blood Pressure Lowering Agents: May enhance the hypotensive effect of Hypotension-Associated Agents.
CNS Depressants: May enhance the sedative effect of Pramipexole.
Hypotension-Associated Agents: Blood Pressure Lowering Agents may enhance the hypotensive effect of Hypotension-Associated Agents.


08/08/2019 17:21:07 Pramipexole
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