Drug Index

Remifentanil

 
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Mechanism :

Binds with stereospecific mu-opioid receptors at many sites within the CNS, increases pain threshold, alters pain reception, inhibits ascending pain pathways.


Indication :

• Analgesic for use during the induction and maintenance of general anaesthesia

• Off-label: Pain management in mechanically-ventilated patients


Contraindications :

Hypersensitivity to remifentanil or any component of the formulation; intrathecal or epidural administration.


Dosing :

Continuous IV infusion:

Neonates and Infants to 2 months: Maintenance of anaesthesia with nitrous oxide (70%): 0.4 mcg/kg/minute (range: 0.4 to 1 mcg/kg/minute); supplemental bolus dose of 1 mcg/kg may be administered.

≥3 months to ≤12 years: Maintenance of anaesthesia with halothane, sevoflurane, or isoflurane: 0.25 mcg/kg/minute (range: 0.05 to 1.3 mcg/kg/minute); supplemental bolus dose of 1 mcg/kg may be administered every 2 to 5 minutes.


Adverse Effect :

Hypotension, bradycardia, shivering, flushing, headache, pruritus, nausea, vomiting, muscle rigidity, respiratory depression, apnea, fever.


Interaction :

Amphetamines: May enhance the analgesic effect of Opioid Analgesics.
Anticholinergic Agents: May enhance the adverse/toxic effect of Opioid Analgesics.
Beta-Blockers: Opioids may enhance the bradycardic effect of Beta-Blockers.
Blood Pressure Lowering Agents: May enhance the hypotensive effect of Hypotension-Associated Agents.
CNS Depressants: May enhance the CNS depressant effect of Opioid Analgesics.
Diuretics: Opioid Analgesics may enhance the adverse/toxic effect of Diuretics.
Opioid Analgesics: CNS Depressants may enhance the CNS depressant effect of Opioid Analgesics.
Selective Serotonin Reuptake Inhibitors: CNS Depressants may enhance the adverse/toxic effect of Selective Serotonin Reuptake Inhibitors.


07/18/2019 12:50:33 Remifentanil
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