Drug Index

Sevoflurane

 
print

Mechanism :

Sevoflurane induces a reduction in junctional conductance by decreasing gap junction channel opening times and increasing gap junction channel closing times. Sevoflurane also activates calcium dependent ATPase in the sarcoplasmic reticulum by increasing the fluidity of the lipid membrane. It also appears to bind the D subunit of ATP synthase and NADH dehydrogenase and also binds to the GABA receptor, the large conductance Ca2+ activated potassium channel, the glutamate receptor, and the glycine receptor.


Indication :

• Induction and maintenance of general anesthesia


Contraindications :

Hypersensitivity to drug/class/component, Malignant hyperthermia history.

Caution if hepatic impairment, Cr >1.5, seizure history or risk, head injury, ICP increase, QT prolongation, neuromuscular disease.


Dosing :

General anesthesia induction and maintenance:

Titrate inhalation to effect. Suitable for mask induction. Give with 100% oxygen.

0-1 months: Induction 3.3% and maintenance 3.5%

1-6 months: Induction 3% and maintenance 3%

6 months to <3 years: Induction 2.8% and maintenance 2.8%

3-12 years: Induction 2.5% and maintenance 2.5%

12-25 years: Induction 2.1% and maintenance 2.1%


Adverse Effect :

Serious Reactions: Malignant hyperthermia, apnea, hyperkalemia, arrhythmias, seizures, hepatotoxicity, increase ICP, anaphylactoid reaction, bronchospasm, airway obstruction, cardiac arrest.

Common Reactions: Nausea/vomiting, agitation, cough, hypotension, laryngospasm, breath holding, bradycardia, tachycardia, airway obstruction, somnolence, shivering, sialorrhea, dizziness, hypertension, apnea.


Interaction :

Avoid/Use Alternative:
Amikacin, Aminophylline, Bedaquiline, Clarithromycin, Doxylamine, Gentamicin, Kanamycin, Methadone, Neomycin, Paromomycin, Pasireotide, Pimozide, Streptomycin, Theophylline, Tobramycin.
Monitor/Modify Treatment:
Acebutolol, Amphetamine, Atenolol, Atracurium, Benzphetamine, Betaxolol, Bisoprolol, Canagliflozin, Carvedilol, Ciprofloxacin, Cisatracurium, Dexmedetomidine, Dextroamphetamine, Dobutamine, Dopamine, Doxapram, Ephedra, Ephedrine, Epinephrine, Esmolol, Isoproterenol, Labetalol, Lisdexamfetamine, Methamphetamine, Metoprolol, Nadolol, Nebivolol, Norepinephrine, Pancuronium, Penbutolol, Phenylephrine Injection, Pindolol, Propranolol, Quinidine (CYP2D6 booster), Riociguat, Rocuronium, Sotalol, Timolol, Tramadol, Trandolapril, Vancomycin, Vecuronium.


07/14/2019 06:45:20 Sevoflurane
ask a doctor
Ask a Doctor
Disclaimer: The information given by www.pediatriconcall.com is provided by medical and paramedical & Health providers voluntarily for display & is meant only for informational purpose. The site does not guarantee the accuracy or authenticity of the information. Use of any information is solely at the user's own risk. The appearance of advertisement or product information in the various section in the website does not constitute an endorsement or approval by Pediatric Oncall of the quality or value of the said product or of claims made by its manufacturer.
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0