Drug Index

Rubella Vaccine

Mechanism :

Rubella Virus Vaccine is a live virus vaccine for vaccination against rubella, is a sterile lyophilized preparation of the live attenuated rubella virus. The virus was adapted to and propagated in human diploid lung fibroblasts.

Indication :

  • Prophylaxis of rubella

Contraindications :

Hypersensitivity to any component of the vaccine, in pregnant females, anaphylactic or anaphylactoid reactions to neomycin, febrile respiratory illness or other active febrile infection, patients receiving immunosuppressive therapy, individuals with blood dyscrasias, leukemia, lymphomas of any type, or other malignant neoplasms affecting the bone marrow or lymphatic systems, primary and acquired immunodeficiency states, including AIDS, and in individuals with a family history of congenital or hereditary immunodeficiency. It is advised in women unimmune to rubella at least 3 months prior to pregnancy to prevent congenital rubella syndrome in the fetus. Avoid in pregnant women.

Dosing :

Deep SC: 0.5 ml given to adolescent girls at 15 years of age. It is also given as part of MMR vaccine 0.5 mL of reconstituted vaccine at 15 months and 4-6 years.
India, along with ten other WHO South East Asia Region member countries, have resolved to eliminate measles and control rubella/congenital rubella syndrome (CRS) by 2020. In this direction, Ministry of Health & Family Welfare has initiated measles-rubella (MR) vaccination campaign in the age group of 9 months to less than 15 years. All children from 9 months to less than 15 years of age will be given a single shot of Measles-Rubella (MR) vaccination during the campaign. Following the campaign, MR vaccine will become a part of routine immunization and will replace measles vaccine, currently given at 9-12 months and 16-24 months of age of child.

Adverse Effect :

Fever, syncope, headache, dizziness, malaise, irritability, arthralgia, arthritis, vasculitis, diarrhea, vomiting, nausea, thrombocytopenia, purpura, regional lymphadenopathy, leucocytosis. Local reactions such as tenderness and redness may occur.

Interaction :

As it is a live vaccine it may be given at the same time as other live vaccines or after a minimum interval of 3 weeks. It should not be given within a period of 3 weeks before and 3 months after human immunoglobulin and blood or plasma transfusions. The vaccine should not be given to children <1-year-old, as maternal antibodies may interfere with the response. A tuberculin test should ideally be postponed until 4 weeks have elapsed since immunization.

Hepatic Dose :

No dosage adjustments are recommended.
02/21/2024 23:44:52 Rubella Vaccine
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