Drug Index


Synonym :

Sertaconazole Nitrate

Mechanism :

Sertaconazole interacts with 14-a demethylase, a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol. As ergosterol is an essential component of the fungal cell membrane, inhibition of its synthesis results in increased cellular permeability causing leakage of cellular contents. Sertaconazole may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and impair triglyceride and/or phospholipid biosynthesis.

Indication :

  • Tinea pedis

Contraindications :

Hypersensitivity to drug/class/component.

Dosing :

<12 years:
Safety and efficacy not established.
>12 years:
Apply cream/lotion (2%) bid for 4 weeks.

Adverse Effect :

Skin reactions, contact dermatitis, xeroderma, application site reaction, erythema, skin burning, and tenderness.

Interaction :

No known interactions.

Hepatic Dose :

No dosage adjustments are recommended.
01/19/2024 07:07:51 Sertaconazole
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