Drug Index

Sulfasalazine

 
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Mechanism :

The mode of action of sulfasalazine or its metabolites, 5-aminosalicylic acid (5-ASA) and sulfapyridine (SP), is still under investigation, but may be related to the anti-inflammatory and/or immunomodulatory properties and to its affinity for connective tissue, and/or to the relatively high concentration it reaches in serous fluids, the liver and intestinal walls.


Indication :

• Inflammatory bowel disease

• Juvenile idiopathic arthritis


Contraindications :

Hypersensitivity to sulfasalazine, its metabolites, sulfonamides or salicylate in patients with intestinal or urinary obstruction and in patients with porphyria, as the sulfonamides have been reported to precipitate an acute attack. Contraindicated in children <2 years of age and caution in patients with G6PD deficiency.


Dosing :

<2 years: Safety and efficacy not established.

≥2 years: Acute Attack or relapse: 40-60 mg/kg/day PO in divided doses, Maintenance Dosage: 20-30 mg/kg/day PO in divided doses.


Adverse Effect :

Cyanosis, hemolytic anemia, stomatitis, elevated hepatic enzymes, leukopenia, thrombocytopenia, hypoglycemia, goitre, nausea, anorexia, vomiting, oligospermia, headache, dyspepsia, rash, abdominal pain, fever, pruritus, dizziness, urticaria, exacerbation of colitis


Interaction :

Digoxin and Folic Acid: May reduce gastrointestinal absorption.
Antibiotics: That alter intestinal flora may interfere with conversion of sulfasalazine to sulfapyridine and 5-aminosalicylic acid (5-ASA) decreasing its effectiveness.


07/18/2019 01:45:44 Sulfasalazine
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