Drug Index


Mechanism :

It is an extended spectrum, semisynthetic penicillin. It is active against both gram-positive and gram-negative bacteria with a good antipseudomonal activity. It is used in treating severe infections associated with pseudomonas.

Indication :

  • Treatment of bacterial infections

Contraindications :

Hypersensitivity to drug/class/component.

Anaphylactic reaction to beta-lactams.

Dosing :

Neonates <7 days old, <2 kg or >7 days old, <1.2 kg: 75 mg/kg/dose every 12 hours.
Neonates <7 days old, >2 kg or >7 days old, 1.2-2 kg: 75 mg/kg/dose every 8 hours.
Neonates >7 days old, >2 kg: 100 mg/kg/dose every 8 hours.
Full-term neonates and above: 200-300 mg/kg/day IV divided every 4-6 hours.
>60 kg: 3 g IV every 4-6 hours.

Adverse Effect :

Decreased platelet aggregation, hypernatremia, hypocalcemia, rash, increased liver enzymes, thrombophlebitis, seizure, Jarisch-Herxheimer reaction, hemolytic anemia, Positive coomb’s test, acute interstitial nephritis.

Interaction :

Penicillin, extended-spectrum
Interaction Characteristics:
Alters GI flora, antiplatelet effects, bactericidal activity requires bacterial growth, lowers seizure threshold.
BCG live intravesical.

Hepatic Dose :

There are no pediatric specific recommendations; based on experience in adult patients, dosing adjustment suggested with concomitant renal dysfunction.
12/12/2023 17:45:39 Ticarcillin
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