Drug Index

Triprolidine

 
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Mechanism :

Triprolidine binds to the histamine H1 receptor. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine.


Indication :

• For the symptomatic relief of

• Seasonal or perennial allergic rhinitis or non-allergic rhinitis

• Allergic conjunctivitis

• Mild, uncomplicated allergic skin manifestations of urticaria and angioedema.

• Usually used in combination with pseudoephedrine for the symptomatic relief of symptoms associated with the common cold.


Contraindications :

Breathing problems (such as asthma, emphysema), a certain eye problem (glaucoma), heart problems, high blood pressure, liver disease, seizures, stomach problems (such as ulcers, blockage), overactive thyroid (hyperthyroidism), urination problems (such as trouble urinating due to enlarged prostate, urinary retention).


Dosing :

6-12 years: 1.25 mg PO every 4-6 hours. Max: 5 mg/day.

>12 years: 2.5 mg PO every 4-6 hours. Max: 10 mg/day.


Adverse Effect :

Drowsiness, dizziness, headache, nausea, vomiting, loss of appetite, constipation, stomach upset, blurred vision, decreased coordination, and dry mouth/nose/throat may occur.


Interaction :

Cyclopentolate Triprolidine and Cyclopentolate: Two anticholinergics may cause additive anticholinergic effects and enhance their adverse/toxic effects. Monitor for enhanced anticholinergic effects.
CNS depressants, Triprolidine and Diazepam: May increase adverse/toxic effects due to additivity. Monitor for increased CNS depressant effects during concomitant therapy.


07/14/2019 07:30:39 Triprolidine
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