ISSN - 0973-0958
   
 
The Effect of Vitamin D Supplementation on Children with Allergic Rhinitis
Piyush Upadhyay1, Rakhi Jain2.
1Department of Pediatrics, Ram Manohar Lohia Institute of Medical Sciences, Lucknow, India, 2Department of Pediatrics, Ganesh Shankar Vidyarthi Memorial Medical College, Kanpur, India.
 
Abstract

Background: Allergic rhinitis (AR) is a common pediatric disorder. Vitamin D is known to have effect on helper T-cells, regulatory T-cells, activated B-cells and dendritic cells linking vitamin D to various immune-related conditions and allergies. Vitamin D can significantly affect the outcome of allergic responses in AR.

Objective: To study the effect of vitamin D supplementation in the treatment of children with AR.

Materials and Methods: Forty-two children with AR and low 25 hydroxy (OH) D3 levels were included in the study. Total Nasal Symptom Score (TNSS) and 25 (OH) D3 levels were measured before and after treatment. They were divided in two groups randomly. Both groups were given standard treatment for AR. One group received oral vitamin D (cholecalciferol: 400-800 IU as per age of the child) for 21 days. The results were compared with the other group being treated similarly but without supplementation of vitamin D.

Results: Clinical improvement in terms of reduction in the TNSS was significant in the post-Vitamin D supplemented group (TNSS score pre-treatment and post treatment were 10.6 ± 2.65 and 2.76 ± 1.6 respectively in Vitamin D supplemented group and 11.04 ± 1.93 and 4.66±1.99 in the pre and post-treatment group in those who were not supplemented) (p=0.01). Significant improvement of Vitamin D levels was found post-treatment in Vitamin D supplemented group (23.06 ± 9.73 ng/ml) as compared to pre-treatment (18.13 ± 4.55 ng/ml) (p<0.05) while there was no significant difference in group not supplemented with Vitamin D (pre and post treatment 18.01 ± 3.95 ng/ml and 17.99 ± 3.83 ng/ml respectively)

Conclusion: Supplementation of vitamin D in patients with AR leads to significant clinical improvement.
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License
Disclaimer: The information given by www.pediatriconcall.com is provided by medical and paramedical & Health providers voluntarily for display & is meant only for informational purpose. The site does not guarantee the accuracy or authenticity of the information. Use of any information is solely at the user's own risk. The appearance of advertisement or product information in the various section in the website does not constitute an endorsement or approval by Pediatric Oncall of the quality or value of the said product or of claims made by its manufacturer.
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0