ISSN - 0973-0958

Pediatric Oncall Journal View Article

Microalbuminuria in Children with Sepsis
Riady Ashari, Munar Lubis, Rina A C Saragih.
Department of Pediatrics, Faculty of Medicine, Universitas Sumatera Utara, North Sumatera, Indonesia.
Sepsis is a major problem which causes increased morbidity and mortality in critically ill children. Its incidence is increasing every year. The manifestations are varied, thus its diagnosis and determination of the severity are very important to prevent complications. Initially, the existence of albumin in urine was used as a predictor of the risk of renal disease and cardiovascular problem. However, it has developed into a marker of various inflammatory conditions as well as prognostic marker of death or even therapy evaluation. In sepsis, endothelial dysfunction will cause systemic capillary leakage which eventually results in the secretion of albumin in urine. Adult studies showed that microalbuminuria (ratio of urinary albumin/creatinine of 30-300 mg/gram) is a simple non-invasive test which not only indicates the systemic inflammatory response but also predict mortality with critical disease. The association of microalbuminuria with mortality in children with sepsis is still poorly investigated.

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