ISSN - 0973-0958

Pediatric Oncall Journal View Article

Neonatal hemochromatosis - A fulminant cause of neonatal cholestasis
Drishti Tolani1, Javed Ahmed2, Khushnuma Mullanfiroze1, Ira Shah1,2.
1Pediatric Liver Clinic, B. J. Wadia Hospital for Children, Mumbai, Maharashtra, India,
2Pediatric Department, Nanavati Hospital, Mumbai, Maharashtra, India.
Abstract
Neonatal hemochromatosis (NH) due to Gestational alloimmune liver disease (GALD) is a rare form of fulminant liver disease of unknown cause characterized by diffuse deposition of iron in the liver and extra hepatic sites without any evidence of increased iron intake. Neonatal cholestasis is characterized by persistent elevation of conjugated bilirubin. It can be caused by infections, biliary atresia, by toxins or by metabolic disorders of the liver. GALD is rarely reported as a cause of fulminant neonatal cholestasis. We present three cases of infants who presented with neonatal cholestasis and were found to have NH as well.

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