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AUTOIMMUNE LIVER DISEASE
Abstract
Full Text
PDF
Volume
11
, Issue
3
July-September 2014
Pages: 61-64
DOI:
https://doi.org/10.7199/ped.oncall.2014.53
CITE THIS ARTICLE
Liberal R, Vergani D, Mieli-Vergani G. AUTOIMMUNE LIVER DISEASE. Pediatr Oncall J. 2014;11: 61-64. doi: 10.7199/ped.oncall.2014.53
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AUTOIMMUNE LIVER DISEASE
Rodrigo Liberal
1
, Diego Vergani
1
, Giorgina Mieli-Vergani
2
.
1
Institute of Liver Studies, King’s College London, UK,
2
Paediatric Liver,GI and Nutrition Centre, School of Medicine at King’s College Hospital, London, UK.
Show affiliations
Abstract
Autoimmune liver disorders in childhood include autoimmune hepatitis (AIH) and autoimmune sclerosing cholangitis (ASC). These inflammatory liver disorders are characterised histologically by interface hepatitis, biochemically by elevated transaminase levels and serologically by autoantibodies and increased levels of immunoglobulin G. AIH is particularly aggressive in children and progresses rapidly unless immunosuppressive treatment is started promptly. With appropriate treatment some 80% of patients achieve remission and long-term survival. For non-responders and difficult-to-treat patients, novel and more effective therapeutic approaches are sought. ASC responds to the same treatment used for autoimmune hepatitis in regards to parenchymal inflammation, but bile duct disease progresses in about 50% of cases, leading to a worse prognosis and a higher liver transplantation requirement; moreover, it has a high recurrence rate after transplant. Progression of liver disease and recurrence after transplant are more common in patients with associated poorly controlled inflammatory bowel disease, which therefore needs to be treated aggressively and effectively.
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Anaphylaxis
Anal fissure
Circumcision
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Renal Calculators
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