Study of risk factors in children with primary non-syndromic craniosynostosis

ORIGINAL ARTICLE

Study of Risk Factors in Children with Primary Non-Syndromic Craniosynostosis

Girish Kumar¹, Sheetal Sharda², A K Bhalla², K S Sodhi³.

¹Department of Neurology, DRPGMC Kangra, Tanda, Himachal Pradesh,
²Department of Pediatrics, PGIMER, Chandigarh,
³Department of Radio diagnosis, PGIMER, Chandigarh, India.

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Abstract
Craniosynostosis (cranio=cranium + syn=together + ostosis=related to bone) is a condition in which one or more of the fibrous sutures in an infant skull prematurely fuses by ossification. Several risk factors for non-syndromic craniosynostosis (NSCS) have been suggested.
Material and Methods: In this observational study we studied the risk factors associated with NSCS in 30 children aged 1 month to 12 years attending pediatric outpatient department in tertiary health care institute in India.
Results: Male: Female ratio was 1.7:1. Twenty-five (83.6%) children belonged to the plains while 5 (16.7%) belonged to the hilly regions from Himachal Pradesh. Ten (33.3%) children were from the rural areas and the rest (66.7%) were from the urban area. The mother’s age at conception was below 30 years in 28 (93.3%) patients. On the other hand 16 (53.3%) of the fathers were above 30 years of age.
Conclusion: Paternal age more than 30 years and male gender is associated with non-syndromic craniosynostosis.

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