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The burden of chronic disease in adolescent’s hospitalizations 12/06/2021 00:00:00 https://www.pediatriconcall.com/Journal/images/journal_cover.jpg

The burden of chronic disease in adolescent’s hospitalizations

André Garrido1, Francisca Costa1, Maria de Lurdes Torre1, Alexandra Dias2.
1Pediatric Department, Hospital Prof. Doutor Fernando Fonseca, E.P.E., Amadora, Portugal,
2Hospital de Dona Estefânia, Lisboa, Portugal.

ADDRESS FOR CORRESPONDENCE
André Garrido, Hospital Prof. Doutor Fernando Fonseca, IC19, 2720-276 Amadora, Portugal.
Email: andre.garrido@hff.min-saude.pt
Abstract
The growing prevalence of chronic disease during adolescence urges health services to adapt. We did a retrospective characterization of adolescent’s hospitalizations in a second-level hospital during five years. We examined adolescent’s most relevant clinical information and the hospital resources used for their admission. We also explored how chronic disease influences data collection.
There were 1018 hospitalizations of adolescents in the pediatric ward during this period with longer length of stay and regular need of hospital resources. Chronic patients represented almost 60% of adolescents’ hospitalizations and, among these, more than two-thirds were related to their chronic disease. This emphasizes the urgency for policy making concerning control optimization of such diseases as well as improving facilities to become more youth-friendly.
 
Keywords
Adolescence, Adolescent Health Services, Hospitalization, Chronic Disease
 
Introduction
Chronic disease affects up to 31.5% adolescents.1,2,3,4,5 Its prevalence is rising due to advances in management and survival of diseases like cystic fibrosis, congenital heart disease, spina bifida, congenital anemias and cancer, and to the increasing incidence of other diseases like obesity and diabetes, asthma, mental disorders, and HIV infection.2,6,7,8 Although mortality decreased in this age group, morbidity and disability are a growing burden.9 The most represented chronic diseases in this age group are asthma and allergies, overweight and obesity, mental health and behavioral problems, and heart disease.5,7,10
The burden of these chronic diseases can affect adolescence development, disturb growth and pubertal maturation, social-emotional development and family issues.4,11 Global health policies are being settled, encouraging day care and home care instead of in-hospital treatment whenever possible and creating facilities that are more youth-friendly.4 The individuals between ten and 19 years of age represented 10.9% of the Portuguese population in 201112 and those between ten and 17 years of age were responsible for 24512 hospital discharges in Portugal in 2018, 2.2% of total national hospital discharges.13 The most prevalent hospital discharge diagnoses of this age group reported in the literature are: injury and mental disease between ten and 14 years old and complications of pregnancy, childbirth and puerperium and also mental disease between 15 and 18 years old.14,15,16
We examined retrospectively the hospitalizations from our hospital to characterize the adolescent hospitalizations and to study the factors that may have contributed to prolonged hospitalizations, namely chronic disease.
 
Methods & Materials
We studied adolescent admissions in the pediatric ward of our hospital: between 13 and 18 years old, since the 1st January of 2012 until the 31st December of 2016. We excluded hospitalizations with only surgical conditions (e.g., simple elective surgery, orthopedic trauma).
Our hospital is a Level II hospital that serves the Lisbon outskirts population with immigrants from Africa, South America, and Eastern Europe.12 Major pediatric trauma and oncology patients are rarely admitted in our hospital. Healthy pregnant adolescents are usually admitted to the obstetric ward.
The following data was collected: age, sex, length of hospital stay, reason for admission, previous medical history and underlying diseases, family and social work department support during admission, other specialists consulted during admission and discharge diagnosis.
Reasons for admission were divided in: acute disease, exacerbation of chronic disease, elective medical procedure (such as prophylactic or therapeutic administrations) and social reasons. The discharge diagnoses were categorized according to International Classification of Diseases, Tenth Revision, Clinical Modification (ICD10) coding and then grouped in broader items, following also ICD10 tabular index.
We reviewed the chronic diseases of each patient, limiting to the three more functionally significant. We used the broad definition of chronic disease proposed by Stein and colleagues.17
The authors performed a descriptive analysis of the data and studied possible correlations between two groups: patients with chronic diseases and patients without chronic diseases.
Statistical analysis was performed using SPSS (version 23.0) software. We used T-test to compare: (a) the mean length of stay of those who were accompanied by a relative with those who were not, (b) those who needed social work department or other medical specialties support with those who did not and, (c) chronic versus non-chronic patients. The Chi-squared test was used to compare: (a) the need for psychiatric/psychological support among those who needed social work department support versus those who did not; (b) compare the need of social work department support between those that had been accompanied by a relative versus those who had not; (c) compare chronic versus non-chronic patients concerning the need for specialties support and transfer to intensive care. Pearson’s chi-squared test was used to compare the different adolescent’s companions of chronic versus non-chronic patients. The significance level was set to 0.05 for all tests and they were all double-sided. This analysis was approved by the ethics committee of our hospital.
 
Results
All Hospitalizations
There were 1018 adolescent hospitalizations in our ward during the study period, representing 13.6% of the total admissions (7507 hospitalizations), with female predominance (61.3%). The median age was 15.8 years (P25:14.4; P75:17.0). The percentage of hospitalizations by age is represented in Table 1.

Table 1. Percentage of hospitalizations and median length of stay by age. Reasons for admission of total hospitalizations and of the hospitalizations of adolescents with chronic disease.
  All hospitalizations Hospitalizations of adolescents with chronic disease
Age (years old) % Median length of stay (days) % Median length of stay (days)
13 17.5 3 (min=1; max=71) 17.1 3 (min=1; max=54)
14 16.6 3 (min=1; max=147) 19.6 3 (min=1; max=147)
15 19.2 4 (min=1; max=98) 15.3 4 (min=1; max=98)
16 21.1 4 (min=1; max=283) 22.5 4 (min=1; max=98)
17 21.8 4 (min=1; max=100) 20.6 4 (min=1; max=59)
18 3.8 5 (min=1; max=231) 4.9 6 (min=1; max=231)
Reasons for admission % of all hospitalizations % of hospitalizations of adolescents with chronic disease
Acute disease 65.3 43.8
Acute exacerbation of chronic disease 27.8 47.5
Elective procedure 4.9 8.1
Social issues 1.2 0.7


The median length of stay was four days comparing to a median length of stay of the total hospitalizations in our ward of three days. The median length of stay by age group can be found in Table 1.
The main reasons for admission were acute disease and acute exacerbation of chronic disease as can be seen in Table 1.
The main discharge diagnosis / assemble of symptoms are grouped by ICD10 coding in Table 2.

Table 2. Frequency of ICD10 group diagnoses of hospital discharge of all adolescent hospitalizations and of hospitalizations of adolescents with chronic disease.
ICD10 Groups All hospitalizations Adolescents with chronic disease
  N % n %
J00-J99 Diseases of the respiratory system 154 15.1 92 15.4
R00-R99 Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified 126 12.3 76 12.7
A00-B99 Certain infectious and parasitic diseases 120 11.8 41 6.9
D50-D89 Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism 100 9.8 88 14.8
G00-G99 Diseases of the nervous system 77 7.6 56 9.4
E00-E89 Endocrine, nutritional and metabolic diseases 69 6.8 54 9.1
N00-N99 Diseases of the genitourinary system 68 6.7 31 5.2
L00-L99 Diseases of the skin and subcutaneous tissue 57 5.6 16 2.7
(ICD-10-PCS Codesa) 0 Medical and Surgical 50 4.9 17 2.9
S00-T88 Injury, poisoning and certain other consequences of external causes 36 3.5 16 2.7
K00-K95 Diseases of the digestive system 35 3.4 27 4.5
F01-F99 Mental, Behavioral and Neurodevelopmental disorders 32 3.1 21 3.5
Z00-Z99 Factors influencing health status and contact with health services 28 2.5 26 4.4
I00-I99 Diseases of the circulatory system 24 2.4 12 2.0
M00-M99 Diseases of the musculoskeletal system and connective tissue 23 2.3 12 2.0
F Physical Rehabilitation and Diagnostic Audiology 7 0.7 7 1.1
C00-D49 Neoplasms 6 0.6 2 0.3
O00-O9A Pregnancy, childbirth and the puerperium 3 0.3 1 0.2
Q00-Q99 Congenital malformations, deformations and chromosomal abnormalities 2 0.2 1 0.2
V00-Y99 External causes of morbidity 1 0.1 0 0
a ICD-10 Procedures Codes


Professionals from other departments were consulted in 60.7% of the hospitalizations: psychology (14.5%); otolaryngology (12.0%); physical medicine and rehabilitation (11.4%); ophthalmology (10.0%); pediatric surgery (8.5%); pediatric cardiology (8.0%); child and adolescent psychiatry (6.1%); gynecology (5.5%); orthopedics (5.0%); pain management multidisciplinary team (0.9%). Professionals from more than one department were consulted in 20.6% of hospitalizations. The mean length of hospital stay in which the support of other specialists was needed was significantly longer, 9.6+18.3 days, compared to 3.7+3.3 days when no support was asked (p<0.001). The adolescents were transferred to the intensive care unit of our hospital in 4.6% of the hospitalizations and in 1.3% of cases to other hospitals.
Analyzing the relative support during hospitalization, in 23.0% of the hospitalizations, patients were most of the time alone. 71.5% were accompanied by one of their parents, 1.1% by a grandparent, 0.9% by their boyfriend/girlfriend and 3.5% by other family members or friends. The mean length of hospital stay was significantly longer for hospitalizations in which patients were most of the time alone (11.2+20.6 days versus 6.1+12.2 days, p<0.001).
The social work department intervened in 14.2% of the admissions. The mean length of hospital stay in this setting was significantly longer: 17.3+35.4 days, contrasting with 5.6+5.1 days in which patients did not required social work department support (p<0.001). In the group of patients that needed social work department support, psychological (33.1% versus 11.5%) and child and adolescent psychiatry (14.5% versus 4.7%) were also significantly more requested (p<0.001). Adolescents with no family support during admission were also the group that needed significantly more support from the social work department (28.6% compared with 9.9%, p<0.001).
In nine cases a maltreatment protocol was reported (0.9% of total hospitalizations): one case of neglect, one case of emotional and physical abuse, one case of physical and sexual abuse and six cases of physical abuse. The adolescents were most of the time alone in 66.7% of these hospitalizations.


Chronic Patients Hospitalizations
Out of 1018 hospitalizations, 596 (58.5%) were of chronic patients, with a female predominance of 64.1%. The median age was 15.9 years (P25: 14.4; P75: 17.0).
The mean length of hospital stay for these hospitalizations was 7.8 ± 17.7 days (max=283; min=1) comparing to 6.6 ± 8.8 days (max=100; min=1) in non-chronic adolescents (p=0.183), although not statistically significant. The patient with the longest length of hospital stay is a chronic patient with quadriplegic cerebral palsy and epilepsy who was hospitalized for multiple illness complications.
In 68.6% of the cases, the cause of admission was related to a chronic disease. The main reasons for admission can be found in Table 1. The main chronic disease found was sickle-cell disease. Table 3 presents the most common chronic disease diagnosis encountered. The main discharge diagnosis / assemble of symptoms are grouped by ICD10 coding in Table 2.

Table 3. The top forty most represented chronic diseases.
Chronic disease n % of hospits.
D57 Sickle-cell disorders 111 18.6
J45 Asthma 72 12.1
E10 Type 1 diabetes mellitus 55 9.2
J30 Vasomotor and allergic rhinitis 36 6.0
E66 Overweight and obesity 34 5.7
G40 Epilepsy and recurrent seizures 30 5.0
C96 Other and unspecified malignant neoplasms of lymphoid, hematopoietic and related tissue 29 4.9
K51 Ulcerative colitis 28 4.7
D83 Common variable immunodeficiency 28 4.7
G43 Migraine 25 4.2
J47 Bronchiectasis 24 4.0
F33 Major depressive disorder, recurrent 23 3.9
F41 Other anxiety disorders 19 3.2
G80 Cerebral palsy 15 2.5
F79 Unspecified intellectual disabilities 13 2.2
F91 Conduct disorders 13 2.2
G90 Disorders of autonomic nervous system 13 2.2
M86 Osteomyelitis 12 2.0
D64 Other anemias 11 1.8
K29 Gastritis and duodenitis 11 1.8
J35 Chronic diseases of tonsils and adenoids 9 1.5
G91 Hydrocephalus 9 1.5
M32 Systemic lupus erythematosus 8 1.3
D86 Sarcoidosis 8 1.3
F90 Attention-deficit hyperactivity disorders 8 1.3
E03 Other hypothyroidism 8 1.3
K59 Other functional intestinal disorders 7 1.2
R11 Nausea and vomiting 7 1.2
D68 Other coagulation defects 6 1.0
N28 Other disorders of kidney and ureter, not elsewhere classified 6 1.0
I10 Essential (primary) hypertension 6 1.0
I51 Complications and ill-defined descriptions of heart disease 6 1.0
K50 Crohn's disease 5 0.8
G93 Other disorders of brain 5 0.8
K90 Intestinal malabsorption 5 0.8
I63 Cerebral infarction 5 0.8
E27 Other disorders of adrenal gland 5 0.8
Z21 Asymptomatic human immunodeficiency virus [HIV] infection status 4 0.7
B69 Cysticercosis 4 0.7
N04 Nephrotic syndrome 4 0.7


Compared with the non-chronic patients group, the group of adolescents with chronic disease required more support from other specialists, namely psychology (17.6% versus 10.2%, p=0.001), physical medicine and rehabilitation (15.1% versus 6.2%, p<0.001), child and adolescent psychiatry (7.6% versus 4.0%, p=0.023), pediatric cardiology (8.2% versus 7.6%, p=0.72) and pediatric pain management team (1.4% versus 0.2%, p=0.089). All these differences were statistically significant except for pediatric cardiology and for pediatric pain management team. In 5.9% of the chronic patient hospitalizations, the adolescent needed intensive care as opposed to 2.8% of the non-chronic (p=0.103).
In the chronic disease group, 24.5% of the adolescents were alone during the admission, when compared with 20.9% in the non-chronic disease group (p=0.199). 70.1% were accompanied by one of their parents (versus 73.5% in the non-chronic group), 1.2% by a grandparent (versus 0.9% in the non-chronic), 0.8% by their boyfriend/girlfriend (versus 0.9% in the non-chronic group group) and 3.4% by other family member or friend (versus 3.8% in the non-chronic group) (p=0.719).
Social work department intervened in 16.3% of the admissions compared with 11.4% in the non-chronic group (p=0.029). Four of these hospitalizations required a maltreatment protocol.
 
Discussion
There were more female than male adolescent hospitalizations, contrasting with the evidence that chronic disease is more prevalent in males.1,4,7,10 This may be due to the absence of trauma hospitalizations in our ward, although admissions for mental disease and obstetric motives were also rare.
We confirmed longer median length of stay of one day when comparing the adolescent’s hospitalizations with the total hospitalizations of the pediatric ward. As reviewed in the literature14, this analysis also confirms a rise in the number of adolescent’s hospitalizations with age. The median length of hospital stay increased with age too, which is also supported by international health statistical reports.18 The mean length of stay was significantly longer in hospitalizations of unaccompanied patients and when other specialties and social work department support were needed.
The top groups of discharge diagnoses were substantially different from the McManus et al. survey.14 This can be explained by local protocols as adolescents admitted with poisoning are commonly hospitalized in our observation room and then transferred for observation in a child and adolescent psychiatric emergency service. Major trauma is usually diverted to other local hospitals and complications of pregnancy, childbirth and the puerperium are hospitalized in the obstetric ward.
However, more importantly, above two thirds of hospitalizations were from adolescents with chronic diseases and more than two thirds of these were related to their chronic disease. Exacerbations of chronic diseases were responsible for more than one fourth of the total hospitalizations and almost half of the chronic patients’ admissions. These results are in line with the most recent analysis that reflect the burden of chronic disease in pediatric hospitalizations.19 The chronic disease group required significantly more support from other specialists. Capacitation of caregivers with technical knowledge and skills, facilitation of communication with clinical staff and the improvement of transitions between hospital and home are fundamental aspects to reduce hospitalizations of adolescents with chronic disease.20,21,22
Family and friends support is of utmost importance in hospitalizations as is reflected by our data. Adolescents with chronic diseases are more frequently unaccompanied and require social work department support more often, thus resulting in significantly longer hospitalizations. Interestingly, they were more regularly accompanied by a grandparent than the non-chronic adolescents which reflects the known importance of these relatives in chronic disease, namely in sickle cell disease.23
Limitations of this analysis include the retrospective nature of the study and are related to the sample selection, since the pediatric department of our hospital does not admit trauma patients or pregnant teenagers. Both groups, we believe, are highly represented in adolescence hospitalizations. This is a level II hospital therefore a central hospital may have different results than ours.
 
Conclusion
The hospitalizations of adolescents represent a significant burden in the pediatric ward with longer length of stay and regular need of other specialties and social work department support. They are frequently unaccompanied which urges for creative measures that promote the adolescents’ well-being in these circumstances. Chronic diseases contribute to an additional pressure in these hospitalizations and constitute a huge burden in these patients’ lives. It is urgent to empower caregivers and community health services with skills to optimize the control of chronic diseases and to improve the accessibility for day care and home care instead of in-hospital treatment whenever possible.
 
Compliance with Ethical Standards
Funding None
 
Conflict of Interest None
 
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DOI: https://doi.org/10.7199/ped.oncall.2023.6

Cite this article as:
Garrido A, Costa F, Torre M d L, Dias A. The burden of chronic disease in adolescent’s hospitalizations. Pediatr Oncall J. 2022 Jan 17. doi: 10.7199/ped.oncall.2023.6
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