Pyrethrins and pyrethroids
 
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They are extracted from chrysanthemum plant and used as insect repellants and pesticides. They are available as sprays, dusts, powders and mats
Route :
Ingestion, inhalation, skin contact
Fatal Dose :
1gm/kg body weight
Fatal Period :
2 to 5 days
Mechanism of action :
They prolong the inactivation of sodium channel by binding it in the inactive state
Clinical Picture :
•Skin contact causes dermatitis and blistering •Paraesthesias, nausea, vomiting, and diarrhea •Inhalation causes rhinorrhea, sore throat, wheezing and dyspnoea •Fasciculations, hyperthermia, altered mental status •Convulsions and coma
Treatment :
•Gastric lavage with activated charcoal •Oils and fats to be avoided •Atropine and oximes are contraindicated •Skin should be washed
07/14/2019 01:50:20 Pyrethrins and pyrethroids
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