Aluminium Phosphide (cephlos) - Poisoning Center

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Aluminium phosphide (cephlos)

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It is white or grey tablets with garlicky odor.
Route :
Ingestion or inhalation
Fatal Dose :
one tablet (3gm)
Fatal Period :
24 hours
Mechanism of action :
It is due to phosphine gas {PH3} gas released on contact with gastric Hcl. Phosphine inhibits respiratory chain enzymes and has cyto toxic action.
Clinical Picture :
•dizziness •vomiting •diarrhea •respiratory distress •cyanosis •cardiac arrhythmia •circulatory failure •convulsions
Treatment :
•Gastric lavage with sodium bicarbonate •Activated charcoal •Antacids reduce absorption of phosphine •Magnesium reduces organ toxicity, hypomagnesia amd arrhthmias •Symptomatic

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