Aspirin (acetyl salicylic acid)
It is white crystalline substance with acidic taste. It is commonly used as an antipyretic and analgesic
Route :
Fatal Dose :
5 to 10 gms
Fatal Period :
few minutes to several hours
Clinical Picture :
Poisoning usually occurs due to idiosyncrasy or consumption of excessive dose • Irritation of stomach, nausea , vomiting, hematemesis, malena • Skin rash • Oedema of face and eyelids • cyanosis • giddiness • pyrexia • buzzing in ears, vertigo, deafness • drowsiness • hypoprothrombinemia • acidosis, ketosis • presence of albumin and glucose in urine Reye’s syndrome: it is sometimes seen in children below 15 years on consumption of aspirin. The main features are acute onset hepatic failure and encephalopathy with residual neurologic manifestations
Treatment :
• Emetics • Gastric lavage with sodium bicarbonate • Forced alkaline diuresis • Peritoneal dialysis and hemodialysis • Vit K to check bleeding • Symptomatic
03/09/2020 14:38:30 Aspirin (acetyl salicylic acid)
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