Curare
 
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Active principle: Curarine, D-tubo-curarine Used as arrow poison
Route :
No poisoning occurs when swallowed.When injected – inability to move
Fatal Dose :
30-60mg
Fatal Period :
1 - 2 hours
Mechanism of action :
• Used therapeutically as a muscle relaxant and anticonvulsant. • Paralysis of voluntary muscles from legs upwards including respiratory muscles
Clinical Picture :
• Headache, vertigo, mydriasis, blurred vision and hypotension • Gradual paralysis of limbs, followed by paralysis of respiratory muscles and death from asphyxia.
Treatment :
• Ligature, incision and suction • Atropine - 0.6 to 1.2mg • Neostigmine – 5 to 10mg i.v. • Physostigmine – 3ml of 1: 200 solutioni.v. • Artificial respiration
07/14/2019 01:29:04 Curare
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