Ethylene glycol
 
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It is a clear, colorless, odowebsiteess, non-volatile liquid with a bitter sweet taste mainly used as an anti-freeze agent.
Route :
Not absorbed through skin
Fatal Dose :
100 – 200ml
Fatal Period :
3days
Mechanism of action :
It is metabolized to glycolaldehyde, glycolic acid and oxalic acid and inhibits oxidative phosphorylation
Clinical Picture :
• Initial symptoms : vomiting, lethargy, ataxia, convulsions and coma • In 12 to 24 hours: tachycardia, tachypnoea, circulatory collapse aand acidosis • In 1 to 3 days: hypocalcemia, oliguria, tubular necrosis an d renal failure
Treatment :
• Gastric lavage • Activated charcoal • Antidote- Ethyl alcohol-1ml, kg, day as 111o percent solution I.V. for 5 days. Even 4-methyl pyrazole is considered to be a better antidote. • I.V. sodium bicarbonate • 10 percent calcium gluconate • In severe cases – haemodialysis`
07/14/2019 01:29:46 Ethylene glycol
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