Question of the Week

Question :

Posted On : 26 Jun 2007

WHEN SOULD WE LABEL A CASE OF MALARIA AS "RESISTANT MALARIA"?

Expert Answer :

No expert answer available.

Answer Discussion :

pramod m.kulkarni

clinically-persistent fever even after appropriate,complete,assimilated parasiticidal dose of an antimalarial agent.
scientifically-WHO defn and resistance category
persistent parasitemia even after adequate assimilated dose of an antimalarial agent.

18 years ago

Dr Sheila Emmanuel

When thereis no response to routinely used drugs

18 years ago

safy nawar

resistant malaria considerd with failure of eradication of parasite through 7-28 days

18 years ago

Dr.D.Nagesh

when the disease is not responded inspite of using chloroquine, quinine.

18 years ago

pediatriconcall

WHO has developed a simple scheme for estimating the degree of resistance that involves studying the parasitemia over 28 days. Smears on day 2, 7 and 28 are done to grade the resistance as R1 to R3. In a case of normal response parasite count to fall to 25 Percent of pre-treatment value by 48 hours and smear should be negative by 7 days.
RI, Delayed Recrudescence: The asexual parasitemia reduces to Less than 25 Percent of pre-treatment level in 48 hours, but reappears between 2-4 weeks.
RI, Early Recrudescence: The asexual parasitemia reduces to Less than 25 Percent of pre-treatment level in 48 hours, but reappears earlier.
RII Resistance: Marked reduction in asexual parasitemia {decrease More than 25 Percent but Less than 75 Percent} in 48 hours, without complete clearance in 7 days.
RIII Resistance: Minimal reduction in asexual parasitemia, {decrease Less than 25 Percent} or an increase in parasitemia after 48 hours.

18 years ago

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