Congenital Leukemia & Hypoplastic Preleukemia

Bharat R Agarwal
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Congenital Leukemia - Management
Congenital leukemia in Down syndrome:
Therapy should be withheld as long as possible, because spontaneous remission may occasionally occur. If disease progresses, hematological or clinical condition deteriorates, appropriate chemotherapy can be administered.

Congenital leukemia with normal blast cell karyotype:
Therapy should be withheld, because spontaneous remission may occasionally occur. If the disease progresses, appropriate therapy can be administered.

Congenital leukemia with chromosomal anomalies in blast cells:

This leukemia progresses clinically and hematologically and requires institution of therapy.

Treatment involves intensive therapy with VP16 or VM-26. This treatment has been found effective in acute monoblastic leukemia of infancy and neonatal leukemia. Allogenic bone marrow transplantation, if a suitably matched bone marrow donor is available, may be indicated when patient is in remission.

Treatment involves intensive therapy with VP16 or VM-26. This treatment has been found effective in acute monoblastic leukemia of infancy and neonatal leukemia. Allogenic bone marrow transplantation, if a suitably matched bone marrow donor is available, may be indicated when patient is in remission.

Supportive transfusions initially. Specific antileukemic chemotherapy, when leukemia is diagnosed.


Congenital Leukemia & Hypoplastic Preleukemia Congenital Leukemia & Hypoplastic Preleukemia 01/04/2001
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