Leukodystrophies - MRI

Priya Chudgar
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Checklist
- Location of white matter abnormalities
- Signal of white matter apart from the affected regions (hypomyelination)
- Cavitation
- Cerebellar involvement
- Head size
- Contrast enhancement

- Macrocephaly is seen in Krabbe's, Alexander's, Canavan's, Hurler syndrome
- White matter changes located posteriorly: ALD
- White matter changes located anteriorly: Alexander's disease
- Periventricular involvement: MLD, ALD
- Involvement of arcuate fibers: Canavan's disease
- High density basal ganglia: Krabbe's disease
- Post contrast enhancement is seen in ALD, Alexander

Alexander's Disease (Fig 1)
Alexander


MLD (Fig 2)
MLD
MLD (Fig 2a)
MLD


ALD (Fig 3)
ALD
ALD (Fig 3)
ALD


Infantile onset leukoencephalopathy (Vacuolation/spongiform changes) (Fig 4)
Infantile onset leukoencephalopathy (Vacuolation/ spongiform
 Changes)
Infantile onset leukoencephalopathy (Vacuolation/spongiform changes) (Fig 4a)
Infantile onset leukoencephalopathy (Vacuolation/ spongiform
 Changes)



Leukodystrophies - MRI Leukodystrophies - MRI 01/10/2001
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