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Dutch criteria for familial hypercholesterolemia (fh)
Dutch Criteria for Familial Hypercholesterolemia (FH)
Entry Criterion
Patient has elevated cholesterol, family history of FH, and/or family history of premature cardiac death
No
Yes
Family History
First-degree relative with premature coronary and/or vascular disease, OR
First-degree relative with known LDL >95th percentile for age and sex
First-degree relative with tendon xanthomata and/or arcus cornealis, OR
Children <18 years with known LDL >95th percentile for age and sex
Clinical History
Patient with premature coronary artery disease
Patient with premature cerebral or peripheral vascular disease
Physical Examination
Tendon xanthomata
Arcus cornealis at age <45 years
Cholesterol Level
LDL in mmol/L (mg/dL)
LDL-C ≥8.5 (330)
LDL-C 6.5 - 8.4 (250 - 329)
LDL-C 5.0 - 6.4 (190 - 249)
LDL-C 4.0 - 4.9 (155 - 189)
DNA Analysis
Functional mutation of LDLR, apoB or PCSK9 gene
Result :
Please check above criteria
Diagnostic Result :
Please fill out required fields.
References
World Health Organization. Familial hypercholesterolemia—report of a second WHO Consultation. Geneva, Switzerland: World Health Organization, 1999. (WHO publication no. WHO/HGN/FH/CONS/99.2).
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