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Dutch criteria for familial hypercholesterolemia (fh)
Dutch Criteria for Familial Hypercholesterolemia (FH)
Entry Criterion
Patient has elevated cholesterol, family history of FH, and/or family history of premature cardiac death
No
Yes
Family History
First-degree relative with premature coronary and/or vascular disease, OR
First-degree relative with known LDL >95th percentile for age and sex
First-degree relative with tendon xanthomata and/or arcus cornealis, OR
Children <18 years with known LDL >95th percentile for age and sex
Clinical History
Patient with premature coronary artery disease
Patient with premature cerebral or peripheral vascular disease
Physical Examination
Tendon xanthomata
Arcus cornealis at age <45 years
Cholesterol Level
LDL in mmol/L (mg/dL)
LDL-C ≥8.5 (330)
LDL-C 6.5 - 8.4 (250 - 329)
LDL-C 5.0 - 6.4 (190 - 249)
LDL-C 4.0 - 4.9 (155 - 189)
* Required
DNA Analysis
Functional mutation of LDLR, apoB or PCSK9 gene
Result :
Please check above criteria
Diagnostic Result :
Please fill out required fields.
References
World Health Organization. Familial hypercholesterolemia—report of a second WHO Consultation. Geneva, Switzerland: World Health Organization, 1999. (WHO publication no. WHO/HGN/FH/CONS/99.2).
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Disease A-Z
Health Topics
Developmental Pediatrics
General Pediatrics
Genetics
Immunodeficiencies
Infectious Diseases
Laboratory Medicine
Neonatology
Nutrition
Pediatric Cardiology
Pediatric Dermatology
View all topics
Featured Articles
Urticaria (hives) and angioedema
Diabetic ketoacidosis
Anal fissure
Skin allergies
Circumcision
Hypospadias
Kids Corner
Drugs & Calculators
Medical Calculators
Drug Calculators
Genetic Calculators
Growth Calculators
View all Calculators
Drug Index
ACE inhibitor
Alkylating agents
Allergies
View all Drugs
Poisoning Center
Aluminum phosphide
Anti-histaminics
Antidepressants
View all Drugs
Medical Eqipments
Monitors
Pumps
Incubators
View all Eqipments
Diagnostic Aid
Consult & Posts
Ask a Doctor
Diagnostic Dilemma
Question of the Week
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Spot Diagnosis
Grand Rounds
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Current Issue
All Issues
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About the Journal
Submit Article
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