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GI and Liver Calculators
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Proposed scoring criteria for the diagnosis of juvenile autoimmune liver disease
Proposed scoring criteria for the diagnosis of juvenile autoimmune liver disease
ANA and/or SMA
*
≥1:20
†
≥1:80
Anti-LKM-1
*
or
≥1:10
†
≥1:80
Anti-LC-1
Positive
†
Negative
Anti-SLA
Positive
Negative
pANNA
Positive
Negative
IgG
>ULN
>1:20 ULN
Liver histology
Compatible with AIH
Typical of AIH
Absence of viral hepatitis (A, B, E, EBV), NASH, Wilson disease, and drug exposure
Yes
No
Presence of extrahepatic autoimmunity
Yes
No
Family history of autoimmune disease
Yes
No
Cholangiography
Normal
Abnormal
Result :
AIH Score :
15
. Definite AIH
ASC Score :
11
. Definite ASC
Note
*
Antibodies measured by indirect immunofluorescence on a composite rodent substrate (kidney, liver, stomach).
†
Addition of points achieved for ANA, SMA, anti-LKM-1, anti-LC-1, and anti-SLA autoantibodies cannot exceed a maximum of 2 points.
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