Antinuclear Antibody Test (ana)

Dr. Ira Shah
Consultant Pediatrician, B.J.Wadia Hospital for Children, Mumbai, India
First Created: 12/03/2001  Last Updated: 08/01/2015

Patient Education

What is antinuclear antibody (ANA)?

Antibodies are substances that are produced by the immune system of the body to fight the germs causing infection.

Sometimes there is abnormal production of antibodies (auto-antibody) that attack the body's own body systems and tissues leading to autoimmune diseases such as systemic lupus erythematosus (SLE), Rheumatoid Arthritis (RA), scleroderma, Sjogren's syndrome, etc.

Antinuclear antibodies (ANA) are unusual antibodies that are directed against the structures within the nucleus of the cells. The presence of ANA indicates the presence of autoimmune disease.

In what other conditions can ANA test be positive?

ANA test may be positive in persons taking antihypertensives (blood pressure-lowering agents) and anticonvulsants (drugs to treat epilepsy) such as procainamide, hydralazine, and phenytoin. These are referred to as drug-induced ANA positive and does not necessarily indicate the presence of disease.

ANA can be produced in patients with lung diseases such primary pulmonary fibrosis, pulmonary hypertension, Gl diseases such as ulcerative colitis, Crohn's disease, primary biliary cirrhosis, alcoholic liver disease; blood diseases such as ITP, hemolytic anemia; skin diseases such as psoriasis and pemphigus as well as in elderly and those persons with a family history of rheumatic diseases.

How is the ANA test performed?

ANA test is performed using a blood test. The antibodies in the blood are exposed in the laboratory to cells. It is then tested whether these antibodies are reactive to various parts of the nucleus of cells.

Antinuclear Antibody Test (ANA) Antinuclear Antibody Test (ANA) 2015-08-01
Disclaimer: The information given by is provided by medical and paramedical & Health providers voluntarily for display & is meant only for informational purpose. The site does not guarantee the accuracy or authenticity of the information. Use of any information is solely at the user's own risk. The appearance of advertisement or product information in the various section in the website does not constitute an endorsement or approval by Pediatric Oncall of the quality or value of the said product or of claims made by its manufacturer.
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0