Drug Related (iatrogenic) Blood Abnormalities & Serum Artefacts

Dr Ira Shah
Consultant Pediatrician, B.J.Wadia Hospital for Children, Mumbai, India
First Created: 04/03/2001 

Introduction

Pattern in Salicylates Ingestion

The commonest cause of high uric acid levels is salicylates ingestion. Diuretics also raise uric acid levels.


BIOCHEMICAL TEST NORMAL RANGE PATIENT VALUES
LOW NORMAL HIGH
S. URIC ACID 2.1-7.4 mg/dl     *

Pattern following diuretic therapy

Elevated uric acid and low Na+ and Cl levels are commonly observed.


BIOCHEMICAL TEST NORMAL RANGE PATIENT VALUES
LOW NORMAL HIGH
CALCIUM
A-8.5-10.5 mg/dl
C-9.5-11.0 mg /dl
  *  
PHOSPHORUS
A-2.5-4.5 mg/dl
C-2.5-5.5 mg/dl
  *  
S.URIC ACID 2.1-7.4 mg/dl     *
SODIUM
137-148 mEq/L *    
POTASSIUM
3.5-5.6 mEq/L   *  
CHLORIDES 99-108 mEq/L *    
BICARBONATE 23.7-31.4 mEq/L   *  
  A-Adult. C-Child,      

Pattern of hemolysed serum

Depending upon the degree of hemolysis (in vitro), LDH, HBDH & SGOT will be elevated.


BIOCHEMICAL TEST NORMAL RANGE PATIENT VALUES
LOW NORMAL HIGH
HBDH (UV KINETIC) 90-220 IU/L     *
LDH (UV KINETIC) 40-110 IU/L     *
SGOT (UV KINETIC) 7-24 IU/L     *

Pattern of Non-Fasting Sample

High levels of triglycerides, cholesterol, urea & alkaline phosphatase may be observed in nonfasting samples.


BIOCHEMICAL TEST NORMAL RANGE PATIENT VALUES
LOW NORMAL HIGH
TRIGLYCERIDES 35-165 mg/dl     *
CHOLESTEROL(Enzymatic) 125-225 mg/dl   *  
ALK. PHOSPHATASE(KINETIC) A-15-65 IU/L
C-70-150 IU/L
    *
BLOOD UREA(KINETIC) 15-45 mg/dl   *  
  A-Adult. C-Child,  

These normal laboratory values may slightly vary from laboratory to laboratory. Please consult your lab for the same.


Drug Related (Iatrogenic) Blood Abnormalities & Serum Artefacts Drug Related (Iatrogenic) Blood Abnormalities & Serum Artefacts Drug Related (Iatrogenic) Blood Abnormalities & Serum Artefacts 04/03/2001
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