Congenital Hypothyroidism- Neonatal Screening

Swati Gadewar (Kolpuru)
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Congenital Hypothyroidism- Neonatal Screening - Introduction
Congenital hypothyroidism is one of the preventable causes of mental retardation if diagnosed within first 3 months of life. Major complications can be prevented if diagnosed early and started on replacement therapy. Early diagnosis is difficult because the clinical signs are not apparent at birth and appear gradually. Thus it is very important to screen newborns for congenital hypothyroidism and it is a routine newborn screening test in most of the developed countries.

Thyroid agenesis or dysgenesis
- Ectopic thyroid gland
- Defective synthesis
- TRH deficiency or insensitivity
- TSH deficiency or insensitivity
- Transplacental passage of antithyroid drug
- Peripheral resistance to thyroid hormone.
- Maternal ingestion of goitrogens


Congenital Hypothyroidism- Neonatal Screening Congenital Hypothyroidism- Neonatal Screening 12/12/2001
Congenital Hypothyroidism - Clinical Manifestations >>
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