Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K)

Recent onset seizure
Exclude metabolic, infectious, or drug causes
Altered ability to function in normal activity due to severe disturbance in the perception of reality (include hallucinations, incoherence, marked loose associations, impoverished thought content, marked illogical thinking, and bizarre, disorganized, or catatonic behavior); exclude uremia and drug causes
Organic brain syndrome
Altered mental function with impaired orientation, memory, or other intellectual function (with rapid onset and fluctuating clinical features), inability to sustain attention to environment, and ≥2 of the following: perceptual disturbance, incoherent speech, insomnia or daytime drowsiness, and increased or decreased psychomotor activity; exclude metabolic, infectious, or drug causes
Visual disturbance
Retinal changes of SLE (include cytoid bodies, retinal hemorrhages, serous exudates or hemorrhages in choroid, and optic neuritis); exclude hypertensive, infectious, or drug causes
New onset sensory or motor neuropathy involving cranial nerves
Lupus headache
Severe, persistent headache (may be migrainous but must be nonresponsive to narcotic analgesia)
New onset stroke
Exclude arteriosclerosis
Ulceration, gangrene, tender finger nodules, periungual infarction, splinter hemorrhages or biopsy, and angiogram proof of vasculitis
≥2 joints with pain and signs of inflammation (i.e., tenderness, swelling, or effusion)
Proximal muscle aching/weakness associated with elevated CPK/aldolase, EMG changes, or a biopsy showing myositis
Heme-granular or RBC urinary casts
>5 RBC/high-power field; exclude stone, infection, or other cause
>0.5 g/24 hours
>5 WBC/high-power field; exclude infection
Inflammatory-type rash
Oral or nasal mucosal ulcers
Pleuritic chest pain with pleural rub/effusion or pleural thickening
Pericardial pain with ≥1 of the following: rub, effusion, or EKG/echocardiogram confirmation
Low complement
CH50, C3, or C4 decreased below lower limit of normal for lab
High DNA binding
increased above normal range for lab
Temp >100.4 °F (38°C)
Exclude infectious causes
Platelets <100 x 109/L
Exclude drug causes
WBC <3 x 109/L
Exclude drug causes

Result :
SLEDAI-2K Score: 0 points
Authors recommend a cutoff of 3 or 4 to define active disease and the need to increase therapy


Research Paper Gladman DD, Ibañez D, Urowitz MB. Systemic lupus erythematosus disease activity index 2000. J Rheumatol. 2002;29(2):288-91.

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