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Sjogren's syndrome
Sjogren's Syndrome
SJOGREN’S SYNDROME CRITERIA
The presence of any four of the following six criteria items provides sensitivity 97.4%, specificity 89.4%.
OCULAR SYMPTOMS: A POSITIVE RESPONSE TO AT LEAST ONE OF THE FOLLOWING QUESTIONS:
Have you had daily, persistent, troublesome dry eyes for more than 3 months?
Do you have a recurrent sensation of sand or gravel in the eyes?
Do you use tear substitutes more than 3 times a day?
ORAL SYMPTOMS: A POSITIVE RESPONSE TO AT LEAST ONE OF THE FOLLOWING QUESTIONS:
Have you had a daily feeling of dry mouth for more than 3 months?
Have you had recurrently or persistently swollen salivary glands as an adult?
Do you frequently drink liquids to aid in swallowing dry food?
OCULAR SIGNS: OBJECTIVE EVIDENCE OF OCULAR INVOLVEMENT DEFINED AS A POSITIVE RESULT FOR AT LEAST ONE OF THE FOLLOWING TWO TESTS:
Schirmer’s I test, performed without anesthesia (<5 mm in 5 minutes)
Rose bengal score or another ocular dye score (>4 according to van Bijsterveld’s scoring system)
HISTOPATHOLOGY
In minor salivary glands (obtained through normal-appearing mucosa) focal lymphocytic sialadenitis, evaluated by an expert histopathologist, with a focus score >1, defined as a number of lymphocytic foci (which are adjacent to normal-appearing mucous acini and contain more than 50 lymphocytes) per 4 mm2 of glandular tissue.
SALIVARY GLAND INVOLVEMENT: OBJECTIVE EVIDENCE OF SALIVARY GLAND INVOLVEMENT DEFINED BY A POSITIVE RESULT FOR AT LEAST ONE OF THE FOLLOWING DIAGNOSTIC TESTS:
Unstimulated whole salivary flow (<1.5 ml in 15 minutes)
Parotid sialography showing the presence of diffuse sialectasis (punctate, cavitary or destructive pattern), without evidence of obstruction in the major ducts
Salivary scintigraphy showing delayed uptake reduced concentration and/or delayed excretion of tracer 20
AUTOANTIBODIES: PRESENCE IN THE SERUM OF THE FOLLOWING AUTOANTIBODIES:
Antibodies to Ro(SSA) or La(SSB) antigens, or both
Result :
Diagnostic criteria
not met
.
Insufficient diagnostic criteria for neurodevelopmental disorder
Reference
Vitali et al. Classification criteria for Sjögren’s syndrome: a revised version of the European criteria proposed by the American-European Consensus Group. Ann Rheum Dis 2002;61:554-558.
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