Diagnostic Dilemma

Is this visceral leishmaniasis or autoimmune hepatitis?


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A 10-year-old girl born of non-consanguineous marriage resident of Bihar, India presented with fever and recurrent jaundice for 4 years. She has fever and jaundice every 15 days that lasted 2-3 months and subsided on treatment. She had bleeding from the mouth 2 years ago. There was no hematemesis, melena, rash, or altered sensorium and abdominal distension. The birth was normal and milestones were normal. She was unimmunized. On examination, weight was 23 kg and height was 126 cm. There was no jaundice. On systemic examination, she had splenomegaly. Other systems were normal. Investigations showed:
• Hemoglobin = 11.6 gm/dl
• WBC count = 4,500/cumm
• Platelet count = 96,000/cumm
• Bilirubin = 0.6 mg/dl
• SGOT = 97 IU/L, SGPT = 65 IU/L
• Total proteins = 6.8 gm/dl, Albumin = 3.3 gm/dl
• Serum alkaline phosphatase = 845 IU/L
• Ultrasound abdomen = Splenohepatomegaly with coarse echotexture of liver and multiple lieno-renal collaterals
• HIV, HBsAg, Anti HCV = Negative
• Bone marrow aspiration = Erythroid hyperplasia
• ANA = 1:40, Anti smooth muscle Antibody, Anti LKM antibody = Negative
• CMV IgM, IgG, Ebstein Barr Virus nuclear antigen = Negative
• 24 hours urine copper = 20
• Liver biopsy = Fibrosis + LD bodies

Is this visceral leishmaniasis or autoimmune hepatitis?
Answer Discussion :
G
Gladys Yonah
bubble
visceral leishmaniasis
1 Day ago
K
kaushal kishore
bubble
visceral leishmaniasis.
2 Days ago

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