Drug Index

Rizatriptan

 
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Mechanism :

Selective agonist for serotonin (5-HT1B and 5-HT1D receptors) in cranial arteries.


Indication :

• Acute treatment of migraine with or without aura


Contraindications :

Hypersensitivity to rizatriptan or any component of the formulation; documented ischemic heart disease or other significant cardiovascular disease, history of stroke or transient ischemic attack; peripheral vascular disease; ischemic bowel disease; uncontrolled hypertension; basilar or hemiplegic migraine; during or within 2 weeks of MAO inhibitors; during or within 24 hours of treatment with another 5-HT1 agonist, or an ergot-containing or ergot-type medication.


Dosing :

Use in children 6 years and above.

<40 kg: 5 mg PO as a single dose.

≥40 kg: 10 mg PO as a single dose.


Adverse Effect :

Dizziness, drowsiness, fatigue, paresthesia, nausea, xerostomia, chest pain, flushing, palpitations, weakness, jaw pain, pharyngeal edema.


Interaction :

Antiemetics (5HT3 Antagonists): May enhance the serotonergic effect of Serotonin Modulators resulting in serotonin syndrome.
Antipsychotic Agents: Serotonin Modulators may enhance the adverse/toxic effect of Antipsychotic Agents.
Ergot Derivatives: May enhance the vasoconstricting effect of Serotonin 5-HT1D Receptor Agonists.
Monoamine Oxidase Inhibitors: May decrease the metabolism of Serotonin 5-HT1D Receptor Agonists.
Opioid Analgesics: May enhance the serotonergic effect of Serotonin Modulators.
Propranolol: May increase the serum concentration of Rizatriptan.


07/14/2019 19:39:56 Rizatriptan
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