Drug Index

Mitoxantrone

 
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Mechanism :

It is an anthracycline. Replication is decreased by binding to DNA topoisomerase II and seems to inhibit the incorporation of uridine into RNA and thymidine into DNA.


Indication :

• Initial treatment of acute non-lymphocytic leukemia

• Secondary progressive or relapsing-remitting multiple sclerosis (MS)

Off-label:

• Acute lymphocytic leukemia (ALL)

• Autologous hematopoietic stem cell transplantation (HSCT) (conditioning regimen)

• Breast cancer (metastatic)

• Hodgkin lymphoma (refractory)

• Non-Hodgkin lymphomas (NHL)

• Pediatric acute myelogenous leukemia (AML)

• Pediatric acute promyelocytic leukemia (APL)

• Relapsed acute myeloid leukemia (AML)


Contraindications :

Hypersensitivity to mitoxantrone or any component of the formulation.


Dosing :

Acute myeloid leukemia (AML) consolidation phase (second course), acute promyelocytic leukemia (APL) consolidation phase (second course):

10 mg/sqm IV once daily for 5 days.


Adverse Effect :

Nausea, alopecia, UTI, amenorrhea, diarrhea, stomatitis, constipation, headache, back pain, cardiotoxicity, myelosuppression, decreased left ventricular ejection fraction, hepatotoxicity, and abnormal transaminases.


Interaction :

Clozapine: Myelosuppressive Agents may enhance the adverse/toxic effect of Clozapine.
Leflunomide: Immunosuppressants may enhance the adverse/toxic effect of Leflunomide.
Vaccines (Live): Immunosuppressants may enhance the adverse/toxic effect of live vaccines.


07/17/2019 10:40:49 Mitoxantrone
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