Drug Index

Etoposide

 
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Mechanism :

Etoposide is a semisynthetic derivative of podophyllotoxin used in the treatment of certain neoplastic diseases. Its effect appears to be at the G2 portion of the cell cycle in mammalian cells. It acts by lysis of cells entering mitosis and cells are inhibited from entering prophase. It also acts by the induction of DNA strand breaks by an interaction with DNA topoisomerase II or the formation of free radicals.


Indication :

• HLH

• AML Induction


Contraindications :

Contraindicated in patients who have known hypersensitivity to etoposide or any component of the formulation. Full blood count, renal and hepatic function should be assessed before each course.


Dosing :

Under 3 years: 3.3 mg/kg/day continuous intravenous infusion for 4 days.

Above 3 years: 100 mg/sqm/day continuous intravenous infusion for 4 days.


Adverse Effect :

Myelosuppression, anaphylactic-like reactions, nausea and vomiting, transient hypotension following rapid intravenous administration, reversible alopecia, constipation, abdominal pain, asthenia, fatigue, malaise, somnolence, dysphagia, optic neuritis, transient cortical blindness, interstitial pneumonitis/pulmonary fibrosis, fever, seizure.


Interaction :

Warfarin: May lead to increased prothrombin time.
Phenobarbital: May increase etoposide clearance.


07/18/2019 09:23:24 Etoposide
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