Drug Index


Mechanism :

Carboplatin is a platinum coordination compound that is used as a cancer chemotherapeutic agent. Carboplatin, like cisplatin, produces predominantly interstrand DNA cross-links rather than DNA-protein cross-links. This effect is apparently cell-cycle nonspecific.

Indication :

  • Neuroblastoma stage IV
  • Neuroectodermal tumors
  • Medulloblastoma
  • Rhabdomyosarcoma
  • Sarcoma
  • Germ cell tumor
  • Glioma
  • Astrocytoma
  • Retinoblastoma
  • Wilms Tumor
  • Liver tumors

Contraindications :

Carboplatin is contraindicated in patients with a history of severe allergic reactions to cisplatin or other platinum-containing compounds, or mannitol. Carboplatin should not be employed in patients with severe bone marrow depression or significant bleeding.

Dosing :

Dosage varies according to the current treatment protocol. An increasing number of protocols determine doses based on glomerular filtration rate (GFR).
Children solid tumor:
300-600 mg/m² IV once in 4 weeks.
Brain tumor:
175 mg/m² IV once a week for 4 weeks.
360 mg/m² IV once in 4 weeks.

Adverse Effect :

Thrombocytopenia, leukopenia, anemia, neutropenia, nausea, vomiting, peripheral neuropathy, ototoxicity, neurotoxicity, elevated creatinine and blood urea, elevated bilirubin, alkaline phosphatase, SGOT.

Interaction :

Nephrotoxic drugs: Adverse effects increased.
Cidofovir: Combination may increase carboplatin levels, risk if toxicity; increase risk of myelosuppression.

Renal Dose :

Dose in Renal Impairment GFR (mL/min)
20-50Dose as in normal renal function.
10-20Dose as in normal renal function.
<10Dose as in normal renal function.

Dose in Patients undergoing Renal Replacement Therapies
CAPDUnknown dialysability. Dose as in GFR<10 mL/min
HDDialysed. Dose as in GFR<10 mL/ min
HDF/High fluxDialysed. Dose as in GFR<10 mL/ min
CAV/VVHDUnknown dialysability. Dose as in GFR=10–20 mL/min

Hepatic Dose :

No dosage adjustments are recommended.
03/20/2024 21:23:22 Carboplatin
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