Drug Index

Cisplatin

 
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Mechanism :

Cisplatin is a platinum coordination compound that is used as a cancer chemotherapeutic agent. Cisplatin produces predominantly interstrand DNA cross-links rather than DNA-protein cross-links. This effect is apparently cell-cycle nonspecific.


Indication :

• Osteogenic sarcoma

• Neuroblastoma stage IV

• Liver tumors

• Infant brain tumor

• Intracranial germ cell tumor


Contraindications :

Cisplatin is contraindicated in patients with pre-existing renal impairment. Cisplatin should not be employed in myelosuppressed patients, or patients with hearing impairment. Cisplatin is contraindicated in patients with a history of allergic reactions to cisplatin or other platinum-containing compounds.


Dosing :

Osteogenic Sarcoma/Neuroblastoma (off-label):

90 mg/sqm IV every 3 weeks or 30 mg/sqm IV every week.

Brain Tumours, Recurrent (off-label):

60 mg/sqm IV daily for 2 consecutive days every 3-4 weeks.


Adverse Effect :

Alopecia, nephrotoxicity, tinnitus, hearing loss, myelosuppression, leukopenia, anemia, thrombocytopenia, nausea and vomiting.


Interaction :

Anticonvulsant agents: May reach sub therapeutic levels during cisplatin therapy.
Nephrotoxic drugs: risk of acute reduction in GFR


07/19/2019 03:23:24 Cisplatin
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