Drug Index


Mechanism :

Cisplatin is a platinum coordination compound that is used as a cancer chemotherapeutic agent. Cisplatin produces predominantly interstrand DNA cross-links rather than DNA-protein cross-links. This effect is apparently cell-cycle nonspecific.

Indication :

  • Osteogenic sarcoma
  • Neuroblastoma stage IV
  • Liver tumors
  • Infant brain tumor
  • Intracranial germ cell tumor

Contraindications :

Cisplatin is contraindicated in patients with pre-existing renal impairment. Cisplatin should not be employed in myelosuppressed patients, or patients with hearing impairment. Cisplatin is contraindicated in patients with a history of allergic reactions to cisplatin or other platinum-containing compounds.

Dosing :

Osteogenic Sarcoma/Neuroblastoma (off-label):
90 mg/m² IV every 3 weeks or 30 mg/m² IV every week.
Brain Tumours, Recurrent (off-label):
60 mg/m² IV daily for 2 consecutive days every 3-4 weeks.

Adverse Effect :

Alopecia, nephrotoxicity, tinnitus, hearing loss, myelosuppression, leukopenia, anemia, thrombocytopenia, nausea and vomiting.

Interaction :

Anticonvulsant agents: May reach sub therapeutic levels during cisplatin therapy.
Nephrotoxic drugs: risk of acute reduction in GFR

Renal Dose :

Dose in Renal Impairment GFR (mL/min)

Dose in Patients undergoing Renal Replacement Therapies
CAPDUnlikely to be dialysed. Dose as in normal renal function
HDNot dialysed. Dose as in GFR<10 mL/min
HDF/High fluxDialysed. Dose as in GFR<10 mL/ min
CAV/VVHDUnknown dialysability. Dose as in GFR=10–20 mL/min

Hepatic Dose :

No dosage adjustments are recommended.
01/18/2024 19:19:24 Cisplatin
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