Drug Index


Synonym :


Mechanism :

Dacarbazine is an anti-cancer agent, which acts by different mechanisms i.e. inhibition of DNA synthesis by acting as a purine analog, action as an alkylating agent and interaction with SH groups.

Indication :

  • Hodgkin’s disease
  • Solid tumors

Contraindications :

Dacarbazine is contraindicated in patients who have demonstrated a hypersensitivity to it in the past and in patients with hepatic and/or renal insufficiency. Dose reduction and close monitoring of hepatic and bone marrow function may be required.

Dosing :

Hodgkin Lymphoma:
150 mg/m² IV every day for 5 days and to be repeated every 4 weeks OR
375 mg/m² IV on first day repeated every 15 days.
Neuroblastoma Combination Therapy (off-label):
800-900 mg/m² IV once on first day and can be repeated after every 3-4 weeks.

Adverse Effect :

Anorexia, nausea, and vomiting, influenza-like syndrome, myalgia, malaise, alopecia, facial flushing, facial paresthesia, significant liver or renal function test, erythematous and urticarial rashes.

Interaction :

Live vaccines: As dacarbazine may impair the immunological responses, administration of live vaccine may lead to the development of a generalized vaccinia.
Phenytoin, Phenobarbitone: May induce dacarbazine metabolism.

Renal Dose :

Dose in Renal Impairment GFR (mL/min)
45-6080% of dose
30-4575% of dose
<3070% of dose, use with caution

Dose in Patients undergoing Renal Replacement Therapies
CAPDLikely dialysability. Dose as in GFR<30 mL/min
HDLikely dialysability. Dose as in GFR<30 mL/min
HDF/High fluxLikely dialysability. Dose as in GFR<30 mL/min
CAV/VVHDLikely dialysability. Dose as in GFR<30 mL/min

Hepatic Dose :

Use with caution. Adjust dose as per clinical response.
02/14/2024 21:58:27 Dacarbazine
Disclaimer: The information given by www.pediatriconcall.com is provided by medical and paramedical & Health providers voluntarily for display & is meant only for informational purpose. The site does not guarantee the accuracy or authenticity of the information. Use of any information is solely at the user's own risk. The appearance of advertisement or product information in the various section in the website does not constitute an endorsement or approval by Pediatric Oncall of the quality or value of the said product or of claims made by its manufacturer.
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0