Drug Index

Cisplatin

 
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Mechanism :

Cisplatin is a platinum coordination compound that is used as a cancer chemotherapeutic agent. Cisplatin produces predominantly interstrand DNA cross-links rather than DNA-protein cross-links. This effect is apparently cell-cycle nonspecific.


Indication :

• Osteogenic sarcoma

• Neuroblastoma stage IV

• Liver tumors

• Infant brain tumor

• Intracranial germ cell tumor


Contraindications :

Cisplatin is contraindicated in patients with pre-existing renal impairment. Cisplatin should not be employed in myelosuppressed patients, or patients with hearing impairment. Cisplatin is contraindicated in patients with a history of allergic reactions to cisplatin or other platinum-containing compounds.


Dosing :

Osteogenic Sarcoma/Neuroblastoma (off-label):

90 mg/sqm IV every 3 weeks or 30 mg/sqm IV every week.

Brain Tumours, Recurrent (off-label):

60 mg/sqm IV daily for 2 consecutive days every 3-4 weeks.


Adverse Effect :

Alopecia, nephrotoxicity, tinnitus, hearing loss, myelosuppression, leukopenia, anemia, thrombocytopenia, nausea and vomiting.


Interaction :

Anticonvulsant agents: May reach sub therapeutic levels during cisplatin therapy.
Nephrotoxic drugs: risk of acute reduction in GFR



Renal Dose :

Dose in Renal Impairment GFR (mL/min)
20-50
10-20
<10

Dose in Patients undergoing Renal Replacement Therapies
CAPDUnlikely to be dialysed. Dose as in normal renal function
HDNot dialysed. Dose as in GFR<10 mL/min
HDF/High fluxDialysed. Dose as in GFR<10 mL/ min
CAV/VVHDUnknown dialysability. Dose as in GFR=10–20 mL/min

Hepatic Dose :

No dosage adjustments are recommended.
05/27/2020 16:55:10 Cisplatin
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