Drug Index


Mechanism :

Aluminium salts are basic inorganic salts that act by neutralizing hydrochloric acid in gastric secretions. Aluminium salts are slowly solubilized in the stomach and react with hydrochloric acid to form aluminium chloride and water. They also inhibit the action of pepsin by increasing the pH and via adsorption. Cytoprotective effects may occur through increases in bicarbonate ion (HCO3-) and prostaglandins.

Indication :

  • Indigestion
  • Hyperacidity
  • Gastritis
  • Peptic ulcers
  • Heartburn due to pregnancy, hiatus hernia or oesophagitis

Contraindications :

Do not use in children under 6 years of age.

Hypersensitivity to drug/class/component.

GI obstruction, Caution if renal impairment or volume depletion.

Dosing :

Do not use in children below 6 years of age. Available as 500 mg/5 ml suspension.
6 to 12 years:
5 ml between meals and at bedtime if required.
>12 years and adults:
10 ml between meals and at bedtime when needed.

Adverse Effect :

Common Reactions: Constipation, hypophosphatemia, abdominal pain.

Serious Reactions: Aluminium intoxication, osteomalacia, encephalopathy.

Interaction :

Sodium citrate
Avoid/Use Alternative:
Amphetamine, Benzphetamine, Deferasirox, Dextroamphetamine, Doxercalciferol, Lisdexamfetamine, Mesalamine, Methamphetamine, Methenamine, Pancrelipase, Paricalcitol, Ponatinib, Potassium Acid Phosphate, Potassium Phosphate, Quinine, Sodium Acid Phosphate, Sodium Phosphate (Supplement), Sodium Polystyrene Sulfonate, Ursodiol.

Hepatic Dose :

No data available regarding dosage adjustment.
01/23/2024 11:34:10 Hydrotalcite
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