Magnesium Hydroxide
Mechanism :
It is an antacid that neutralizes the hydrochloric acid produced in the stomach. Its suspension "Milk of Magnesia" is used as a laxative and topically to cure "aphthous ulcers".
Indication :
- Constipation
- Acidity
- Hypomagnesemia
Contraindications :
Hypersensitivity to magnesium, low potassium levels, renal failure as magnesium levels would rise steeply.
Dosing :
Suspension:
(5 ml = 400 mg)
2 to 5 years:
2.5-5 mL orally once a day or in divided doses.
6 to 12 years:
5-10 mL orally once a day or in divided doses.
13 to 18 years:
7.5-15 mL orally once a day or in divided doses.
Chewable tablet:
(1 tablet = 400 mg)
3 to 5 years:
2 tablets orally once a day or in divided doses.
6 to 11 years:
4 tablets orally once a day or in divided doses.
12 to 18 years:
8 tablets orally once a day or in divided doses.
Use of magnesium salts is generally contraindicated in renal failure.
Adverse Effect :
It may retard the absorption of a few drugs, hypermagnesemia, hypotension, muscle weakness, CNS depression, abdominal cramping, diarrhea, hypotension, severe allergic reactions, loss of appetite, nausea, slow reflexes, vomiting, EKG changes, respiratory depression, mental depression and coma.
Interaction :
Dolutegravir, Sodium Polystyrene Sulphonate: Major interaction.
Hepatic Dose :
No dose adjustments are recommended.