Drug Index

Procainamide

 
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Mechanism :

It is an amide derivative of procaine used in the treatment of atrial and ventricular arrhythmias.


Indication :

• Ventricular arrhythmias

• Supraventricular arrhythmias


Contraindications :

Hypersensitivity to drug/class/component, SLE , 2nd or 3rd degree AV block, Torsades de pointes, Congenital long QT syndrome, uncorrected Electrolyte abnormalities.


Dosing :

Use in atrial fibrillation and flutter only after the ventricular rate is stabilized.

IV: Initial loading dose of 3-6 mg/kg over 5 mins; Maximum: 100 mg/dose. May be repeated to maximum of 15 mg/kg/dose every 5-10 mins as and when required; followed by maintenance dose of 0.02-0.08 mg/kg/min IV infusion. Maximum dose: 2 g/day.


Adverse Effect :

GI irritation, drug fever, tachycardia, SLE like syndrome, hepatomegaly, positive Coomb’s test, asystole, myocardial depression, hypotension and AV block.


Interaction :

Cimetidine, Ranitidine, Amiodarone, Beta- Blockers, Trimethoprim: Procainamide adjustments required.


07/18/2019 09:24:48 Procainamide
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