Drug Index

Nalidixic acid

Mechanism :

It is an antibacterial agent with good gram-negative action. It is used in the treatment of urinary tract infections, diarrhea and dysentery.

Indication :

  • Lower urinary tract infections due to gram negative organisms such as E. Coli, Klebsiella, Proteus.

Contraindications :

Hypersensitivity, Infants <3 years old, Treatment of febrile patients in whom renal involvement is likely, Porphyria.

Dosing :

55 mg/kg/day in 3-4 divided doses PO.

Adverse Effect :

Drowsiness, weakness, headache and vertigo, double vision, skin rash, blood dyscrasias, convulsions, raised intracranial tension and photosensitivity.

Interaction :

CYP 1A2 inhibitor: Antacids; Sucralfate; Iron; Multivitamins containing zinc; Didanosine; NSAIDS;

Theophylline: Nalidixic acid decreases theophylline.

Melphalan: Increases incidence of severe hemorrhagic colitis.

Warfarin: Increases anticoagulant effect.

Renal Dose :

Dose in Renal Impairment GFR (mL/min)
20-50Dose as in normal renal function
10-20Dose as in normal renal function

Dose in Patients undergoing Renal Replacement Therapies
CAPDUnlikely to be dialysed. Dose as in GFR<10 mL/min
HDUnlikely to be dialysed. Dose as in GFR<10 mL/min
HDF/High fluxUnlikely to be dialysed. Dose as in GFR<10 mL/min
CAV/VVHDUnknown dialysability. Dose as in normal renal function

Hepatic Dose :

Use with caution. Hepatic dysfunction is reported.
02/16/2021 04:31:06 Nalidixic acid
Disclaimer: The information given by www.pediatriconcall.com is provided by medical and paramedical & Health providers voluntarily for display & is meant only for informational purpose. The site does not guarantee the accuracy or authenticity of the information. Use of any information is solely at the user's own risk. The appearance of advertisement or product information in the various section in the website does not constitute an endorsement or approval by Pediatric Oncall of the quality or value of the said product or of claims made by its manufacturer.
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0