Drug Index


Mechanism :

It is an antibacterial agent of the fluoroquinolone group. It useful against gram positive and gram-negative organisms. It is also used as an additional agent in the treatment of multidrug resistance tuberculosis.

Indication :

  • Diarrhea
  • UTI
  • Typhoid
  • Multidrug resistant tuberculosis.
  • Drops: are used for the following conditions:
  • Bacterial conjunctivitis
  • Corneal ulcer
  • Otitis externa
  • Acute otitis media with tympanostomy tubes or chronic suppurative otitis media with perforated tympanic membrane.

Contraindications :

Prolonged QT interval, Hypokalemia, Myasthenia gravis, Hypersensitivity.

Dosing :

10-15 mg/kg/day in 2 divided doses PO/IV. Max: 400 mg/dose.
Bacterial conjunctivitis, Corneal ulcer: Available as 0.3% ophthalmic solution.
>1 year:
Day 1 and 2 put 1-2 drops in affected eye every 2-4 hours. From day 3-7, put 1-2 drops, every 6 hours until clinical cure.
Otitis media:
Available as 0.3% otic drops
1-12 years: 5 drops in affected ear twice daily.
>12 years: 10 drops in affected ear twice daily.
Give for 1 week for acute otitis media with tympanostomy tubes and for 2 weeks for chronic suppurative otitis media with perforated tympanic membrane.

Adverse Effect :

Nausea, vomiting, abdominal pain, leukopenia, eosinophilia.

Ocular preparation: Ocular burning, eye pain, pruritus, stinging, tearing, dryness, blurred vision, foreign body sensation, photophobia, conjunctival hyperemia, chemical conjunctivitis/keratitis, periocular oedema.

Otic preparation: Application site reactions, pruritus, earache, rash, vertigo, taste perversion, dizziness, paresthesia.

Interaction :

Interaction Characteristics:
CYP1A2 inhibitor weak, alters GI flora, binds to polyvalent cations, hyperglycemia, hypoglycemia, lowers seizure threshold, photosensitivity, prolongs QT interval probable.
Amiodarone, BCG live intravesical, cisapride, disopyramide, dofetilide, dronedarone, ibutilide, pimozide, procainamide, quinidine (antiarrhythmic), sotalol, thioridazine, ziprasidone.

Renal Dose :

Dose in Renal Impairment GFR (mL/min)
20-50200–400 mg once daily
10-20200–400 mg once daily
<10200 mg once daily

Dose in Patients undergoing Renal Replacement Therapies
CAPDNot significantly dialysed. Dose as in GFR<10 mL/min
HDDialysed. Dose as in GFR<10 mL/ min
HDF/High fluxDialysed. Dose as in GFR<10 mL/ min
CAV/VVHDDialysed. Dose as in GFR=10– 20 mL/min

Hepatic Dose :

Establishment of safety profile has not been done. In severe hepatic impairment half of maximum dose should not be exceeded.
01/24/2024 03:16:52 Ofloxacin
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