Drug Index



Mechanism :

Cycloserine is an analog of the amino acid D-alanine. It interferes with an early step in bacterial cell wall synthesis in the cytoplasm by competitive inhibition of two enzymes, L-alanine racemase, which forms D-alanine from L-alanine, and D-alanylalanine synthetase, which incorporates D-alanine into the pentapeptide necessary for peptidoglycan formation and bacterial cell wall synthesis.

Indication :

• Mycobacterium avium complex (MAC)

• Multi-drug resistant tuberculosis (TB).

Contraindications :

Hypersensitivity; Alcohol use; Renal dysfunction, severe; History of seizure disorder, mental depression, severe anxiety or psychosis.

Dosing :

15-20 mg/kg/day (Oral) in divided doses upto 1 g/day for a period of 18-24 months.

Adverse Effect :

Confusion, dizziness, headache, somnolence, seizure, vertigo, arrhythmias and heart failure.

Interaction :

Ethanol: May increase risk of cycloserine-assoc. CNS toxicity, seizures (additive toxicity).

03/09/2020 14:57:54 Cycloserine
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